Plasma levels and beta-adrenoceptor blockade with acebutolol, practolol and propranolol in man.
نویسندگان
چکیده
منابع مشابه
Plasma propranolol levels in the quaniitative assessment of beta-adrenergic blockade in man.
Plasma propranolol levels associated with reductions in endogenous and exogenous cardiac beta-stimulation were determined in normal people. The levels associated with a given degree of blockade of exercise-induced tachycardia were about three times greater after intravenous administration than after oral administration. This shows that an active metabolite of propranolol is formed only after th...
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In an attempt to further clarify the mechanism of the maintenance of the antihypertensive effect of beta-adrenoceptor antagonists, the effects of four antagonists with different ancillary properties (acebutolol, atenolol, pindolol, and propranolol) on systemic and renal hemodynamics, body fluid volumes, hormones, and lymphocyte beta-adrenoceptor density were studied in four groups of 10 hyperte...
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The pharmacodynamic activities of two beta adrenergic antagonists, propranolol and practolol, were compared in eight hypertensive patients. The activity of each antagonist was established in relation to its blood concentration at maximal and submaximal adrenergic blockade defined by inhibition of exercise tachycardia. Maximal inhibition of exercise tachycardia was comparable with both drugs and...
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A potential for impaired cardiovascular performance among anesthetized patients due to preoperative treatment with propranolol was considered based on clinical observation of sudden, irretractable cardiac failure in five patients. As a result, a recommendation to terminate beta-adrenoceptor therapy prior to general anesthesia was advanced. During the ensuing decade many clinical researchers sou...
متن کاملBeta adrenoceptor subtype binding activity in plasma and beta blockade by propranolol and beta-1 selective bisoprolol in humans. Evaluation with Schild-plots.
In the present study we investigated whether the beta adrenoceptor subtype binding activity in plasma samples can predict selective and nonselective beta blockade in humans. From the right shifts of isoprenaline dose-response curves 0 to 84 hr after administration of propranolol and the beta-1 selective bisoprolol, in vivo beta blockade was assessed. In an in vitro radioreceptor assay with memb...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1975
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1975.tb00471.x